Ammonia → HCID 12920006, compound

HRID 1577315Notes

Reaction equation

HRID 1577315 reaction equation
[NH3:1].[Cl:2][C:3]1[N:12]=[C:11](Cl)[C:10]2[C:5](=[C:6]([O:17][CH3:18])[C:7]([O:15][CH3:16])=[C:8]([Cl:14])[CH:9]=2)[N:4]=1>O1CCCC1>[Cl:2][C:3]1[N:12]=[C:11]([NH2:1])[C:10]2[C:5](=[C:6]([O:17][CH3:18])[C:7]([O:15][CH3:16])=[C:8]([Cl:14])[CH:9]=2)[N:4]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 12920004HCID 12920004, compound

Product 1

HCID 12920006HCID 12920006, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ammonia was passed into a solution of 2,4,6-trichloro-7,8-dimethoxyquinazoline (31.4 g., 0.107 mole) in 650 ml. dry tetrahydrofuran for one hour at room temperature. After stirring for an additional hour, the suspension was concentrated in vacuo and filtered. The solid was resuspended in water, filtered, washed with water and methanol. Recrystallization from dimethylformamide/water yielded 23.7 g. (81%) of the desired product, M.P., 360° C.

Workup

  1. concentrationthe suspension was concentrated in vacuo
  2. filtrationfiltered
  3. filtrationfiltered
  4. washwashed with water and methanol
  5. customRecrystallization from dimethylformamide/water
  6. customyielded 23.7 g

Sources & evidence

ORD record
ord-41e11c01e8bb48b7872fabce2c5951bb
Source dataset
uspto-grants-1981_09
Patent number
US04287341

Reaction notes

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