反应详情

A mixture of ethyl 3,10-dihydro-10-oxo-1H-pyrido[1,2-a]thieno-[3,4-d]pyrimidine-7-carboxylate (2.0 g., 0.0072 mol) and N-chlorosuccinimide (0.97 g., 0.0072 mol) in pyridine (20 ml) is heated on a steam bath for 18 minutes. The reaction mixture is cooled and poured into a large volume of ice water. The precipitate is filtered, washed with water and dried. Recrystallization from ethanol gives the product (1.1 g.), mp 175°-176° C.

1. temperatureis heated on a steam bath for 18 minutes
2. temperatureThe reaction mixture is cooled
3. filtrationThe precipitate is filtered
4. washwashed with water
5. customdried
6. customRecrystallization from ethanol
7. customgives the product (1.1 g.), mp 175°-176° C.