Chlorosuccinimide → HCID 12953049, compound

HRID 1577411Notes

Reaction equation

HRID 1577411 reaction equation
[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:10]=[CH:11][C:6]2=[N:5][C:4]2[CH2:17][S:18][CH2:19][C:3]1=2.ClN1C(=O)CCC1=O>N1C=CC=CC=1>[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:10]=[CH:11][C:6]2=[N:5][C:4]2=[CH:17][S:18][CH:19]=[C:3]12

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 12953041HCID 12953041, compound

Product 1

HCID 12953049HCID 12953049, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of ethyl 3,10-dihydro-10-oxo-1H-pyrido[1,2-a]thieno-[3,4-d]pyrimidine-7-carboxylate (2.0 g., 0.0072 mol) and N-chlorosuccinimide (0.97 g., 0.0072 mol) in pyridine (20 ml) is heated on a steam bath for 18 minutes. The reaction mixture is cooled and poured into a large volume of ice water. The precipitate is filtered, washed with water and dried. Recrystallization from ethanol gives the product (1.1 g.), mp 175°-176° C.

Workup

  1. temperatureis heated on a steam bath for 18 minutes
  2. temperatureThe reaction mixture is cooled
  3. filtrationThe precipitate is filtered
  4. washwashed with water
  5. customdried
  6. customRecrystallization from ethanol
  7. customgives the product (1.1 g.), mp 175°-176° C.

Sources & evidence

ORD record
ord-38fcdc51be064f329191e2f93fac662d
Source dataset
uspto-grants-1981_09
Patent number
US04287340

Reaction notes

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