Chlorosuccinimide → HCID 12953049, compound

HRID 1577417Notes

Reaction equation

HRID 1577417 reaction equation
[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:10]=[CH:11][C:6]2=[N:5][C:4]2[CH2:17][CH2:18][S:19][C:3]1=2.ClN1C(=O)CCC1=O>N1C=CC=CC=1>[O:1]=[C:2]1[N:7]2[CH:8]=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:10]=[CH:11][C:6]2=[N:5][C:4]2=[CH:3][S:19][CH:18]=[C:17]12

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 12953045HCID 12953045, compound

Product 1

HCID 12953049HCID 12953049, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of ethyl 3,10-dihydro-10-oxo-1H-pyrido[1,2-a]thieno-[3,2-d]pyrimidine-7-carboxylate (0.4 g., 0.0014 mol) and N-chlorosuccinimide (0.9 g., 0.0014 mol) in pyridine (4 ml) is heated on a steam bath for 18 minutes. The reaction mixture is cooled and poured into a large volume of ice water. The precipitate is filtered, washed with water and dried. Recrystallization from ethanol gives the product (0.2 g.) mp 188°-190° C.

Workup

  1. temperatureis heated on a steam bath for 18 minutes
  2. temperatureThe reaction mixture is cooled
  3. filtrationThe precipitate is filtered
  4. washwashed with water
  5. customdried
  6. customRecrystallization from ethanol
  7. customgives the product (0.2 g.) mp 188°-190° C.

Sources & evidence

ORD record
ord-cd3b3d4998f0405cb3fb55dfb8125102
Source dataset
uspto-grants-1981_09
Patent number
US04287340

Reaction notes

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