反应详情

A mixture of 10-oxo-10H-pyrido[1,2-a]thieno[3,4-d]pyrimidine-7-carbonitrile (0.058 g., 0.0003 mol), sodium azide (0.074 g., 0.0011 mol) and ammonium chloride (0.061 g., 0.0011 mol) in dimethylformamide (15 ml) is heated at 95°-100° C. under nitrogen for 46 hours. The solvent is evaporated. The residue is triturated with 1 N hydrochloric acid, filtered and sucked dry to give the product, mp 300° C. (dec).

1. temperatureis heated at 95°-100° C. under nitrogen for 46 hours
2. customThe solvent is evaporated
3. customThe residue is triturated with 1 N hydrochloric acid
4. filtrationfiltered
5. customsucked dry
6. customto give the product, mp 300° C. (dec)