Hydrogen Bromide → HCID 70573577, compound

HRID 1577444Notes

Reaction equation

HRID 1577444 reaction equation
[C:1]([CH2:3][O:4][C:5]1[CH:14]=[C:13]2[C:8]([CH:9]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=3)[CH2:10][C:11]([CH3:16])([CH3:15])[O:12]2)=[CH:7][CH:6]=1)#[N:2].[BrH:27]>[Pd].C(O)C>[BrH:27].[NH2:2][CH2:1][CH2:3][O:4][C:5]1[CH:14]=[C:13]2[C:8]([CH:9]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:24])[F:25])[CH:18]=3)[CH2:10][C:11]([CH3:15])([CH3:16])[O:12]2)=[CH:7][CH:6]=1

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 20570498HCID 20570498, compound

Product 1

HCID 70573577HCID 70573577, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 7-cyanomethyloxy-2,2-dimethyl-4-(3-trifluoromethylphenyl) chroman (5.4 g) and 10% palladium on charcoal (0.5 g) in ethanol (75 ml) was hydrogenated at atmospheric pressure. The catalyst was removed by filtration and the filtrate evaporated under reduced pressure to give an oil which was treated with ethereal hydrogen bromide to give the title compound (4 g) as a very hygroscopic noncrystalline compound.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated under reduced pressure
  3. customto give an oil which

Sources & evidence

ORD record
ord-80b577c9278f4c57b7b7993c02dc21e3
Source dataset
uspto-grants-1981_09
Patent number
USRE030739

Reaction notes

Loading…