反应详情

Into a 200 ml four necked flask, there were charged benzene (100 ml), α,α-dimethylbenzylamine (9 g) and triethylamine (7.4 g), and α-bromo-tert-butylacetyl chloride (14.5 g) was dropwise added thereto while stirring at room temperature. Stirring was continued for 3 hours. The reaction mixture was washed with water to remove triethylamine hydrochloride. After the benzene layer was dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure. The obtained residue was recrystallized from ethanol to give 15.3 g of N-(α,α-dimethylbenzyl)-α-bromo-tert-butylacetamide. M.P., 182°-183° C.

1. additionwas dropwise added
2. stirringStirring
3. washThe reaction mixture was washed with water
4. customto remove triethylamine hydrochloride
5. dry with materialAfter the benzene layer was dried over anhydrous sodium sulfate
6. distillationthe solvent was distilled off under reduced pressure
7. customThe obtained residue was recrystallized from ethanol