Methyl isothiocyanate → N-[2-[[5-(Dimethylaminomethyl)-4-methyl-2-furanylmethyl]thio]ethyl]-N'-methylthiourea

HRID 1577508Notes

Reaction equation

HRID 1577508 reaction equation
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[O:10][C:9]([CH2:11][N:12]([CH3:14])[CH3:13])=[C:8]([CH3:15])[CH:7]=1.[CH3:16][N:17]=[C:18]=[S:19]>C(#N)C>[CH3:13][N:12]([CH2:11][C:9]1[O:10][C:6]([CH2:5][S:4][CH2:3][CH2:2][NH:1][C:18]([NH:17][CH3:16])=[S:19])=[CH:7][C:8]=1[CH3:15])[CH3:14]

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 131251172-[(5-Dimethylaminomethyl-4-methyl-2-furyl)methylthio]ethylamine

Product 1

HCID 20570933N-[2-[[5-(Dimethylaminomethyl)-4-methyl-2-furanylmethyl]thio]ethyl]-N'-methylthiourea

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 5-[[2-(amino)ethyl]thio]methyl-N,N,3-trimethyl-2-furanmethanamine (0.5 g) and methylisothiocyanate (0.15 ml) in dry acetonitrile was stirred for 24 hours.

Sources & evidence

ORD record
ord-4bdc598375c547bcb0bfd9b905d88798
Source dataset
uspto-grants-1981_09
Patent number
US04288443

Reaction notes

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