Ethyl 2-bromopropionate → Ethyl 2-(2,2,2-trifluoro-1-phenylethoxy)propanoate

HRID 1577590Notes

Reaction equation

HRID 1577590 reaction equation
[Na].[F:2][C:3]([F:13])([F:12])[CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[O-:5].[CH2:14]([O:16][C:17](=[O:21])[CH:18](Br)[CH3:19])[CH3:15]>>[CH2:14]([O:16][C:17](=[O:21])[CH:18]([O:5][CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]([F:12])([F:13])[F:2])[CH3:19])[CH3:15]

Participants

3

Reactant 2

HCID 79040Ethyl 2-bromopropionateHCID 86738004Sodium 2,2,2-trifluoro-1-phenylethanolate

Product 1

HCID 20571138Ethyl 2-(2,2,2-trifluoro-1-phenylethoxy)propanoate

Procedure

Using the same procedure as in Example I, Step B, starting from 10.3 g sodium-2,2,2-trifluoro-1-phenylethanolate and 9.4 g ethyl-2-bromopropionate, 6.2 of the title compound is isolated.

Sources & evidence

ORD record
ord-c852748692e047148c4e0a7674ab6624
Source dataset
uspto-grants-1981_09
Patent number
US04288453

Reaction notes

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