Nadide (JAN/USAN/INN) → Lactate

HRID 1577616Notes

Reaction equation

HRID 1577616 reaction equation
[C:1]([O-:9])(=[O:8])[C@H:2]([CH2:4][C:5]([O-:7])=[O:6])[OH:3].C1C=[N+]([C@@H]2O[C@H](COP(OP(OC[C@H]3O[C@@H](N4C5N=CN=C(N)C=5N=C4)[C@H](O)[C@@H]3O)(O)=O)(O)=O)[C@@H](O)[C@H]2O)C=C(C(N)=O)C=1>P([O-])([O-])([O-])=O>[C:1]([O-:9])(=[O:8])[CH:2]([CH2:4][C:5]([O-:7])=[O:6])[OH:3].[C:1]([O-:9])(=[O:8])[CH:2]([CH3:4])[OH:3]

Participants

5

Reactant 2

HCID 5893Nadide (JAN/USAN/INN)HCID 5459792HCID 5459792, compound

Product 2

HCID 91435LactateHCID 160434DL-Malate

Reagents, catalysts & solvents 1

HCID 1061PhosphateSolvent

Procedure

0.35 g of the preparation from Example 18 were added to 10 ml 33 mM L-malate in 0.1 M phosphate pH 4.0 together with 17 μmol NAD+ and 7 μmol MnCl2. Total conversion of malate to lactate was obtained in six hours, and the procedure could be repeated with fresh malate, NAD+ and MnCl2 at least five times without any increase in reaction times.

Workup

  1. custom0.35 g of the preparation from Example 18

Sources & evidence

ORD record
ord-f7efc6282c9e47f58696d16f8f44aa02
Source dataset
uspto-grants-1981_09
Patent number
US04288552

Reaction notes

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