Hydrochloric Acid → HCID 13017870, compound

HRID 1577674Notes

Reaction equation

HRID 1577674 reaction equation
[C:1]1([CH:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]3([CH2:20][CH2:19][C:18]4(OCC[O:21]4)[CH2:17][CH2:16]3)[O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>CO>[C:1]1([CH:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]3([CH2:16][CH2:17][C:18](=[O:21])[CH2:19][CH2:20]3)[O:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13017869HCID 13017869, compound

Product 1

HCID 13017870HCID 13017870, compoundYield 71.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 3.22 g of 3"-phenyldispiro[1,3-dioxolane-2,1'-cyclohexane-4',1"(3"H)-isobenzofuran], 350 ml of methanol and 10 ml of 5% hydrochloric acid is stirred at room temperature for 4 hours. The solvent is removed under reduced pressure and the residue crystallizes with 50 ml of water, suction filtered, washed with water and dried. Recrystallization from 200 ml of hexane provides 71.8% of product, mp 143°-145° C.

Workup

  1. customThe solvent is removed under reduced pressure
  2. customthe residue crystallizes with 50 ml of water, suction
  3. filtrationfiltered
  4. washwashed with water
  5. customdried
  6. customRecrystallization from 200 ml of hexane

Sources & evidence

ORD record
ord-58dff5df543b43a2b71d34323deb3109
Source dataset
uspto-grants-1981_09
Patent number
US04288623

Reaction notes

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