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Acetic Acid → 6,7,8,9-Tetrahydro-3-hydroxy-2-phenyl-5H-thiazolo[3,2-a]azepinium bromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Bromo(phenyl)acetic acid | HCID 97919 | — |
| 反応物 | Thiocaprolactam | HCID 3003736 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 6,7,8,9-Tetrahydro-3-hydroxy-2-phenyl-5H-thiazolo[3,2-a]azepinium bromide | HCID 12922544 | 86% |
反応手順
An acetic acid (50 ml.) solution of ω-thiocaprolactam (6.5 g., 0.05 mole) and α-bromophenylacetic acid (10.8 g., 0.05 mole) was heated on a steam bath for 1/2 hour. The solution was first cooled and diluted with ether. Upon scratching solid which precipitated was collected. The crude material was recrystallized from acetonitrile. The purified material weighed 14 g. (86% yield) and melted at 172°-175° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04289697 |
| 出典データセット | uspto-grants-1981_09 |
| ORD ID | ord-fa8bfd2025d446bdbd73b628eeadd99d |
| 出典メモ | uspto-grants-1981_09 |