Bromo(phenyl)acetic acid → HCID 12922546, compound

HRID 1577772Notes

Reaction equation

HRID 1577772 reaction equation
[C:1]1(=[S:7])[NH:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:8][CH:9]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:10](O)=[O:11]>CC(C)=O>[Br-:8].[OH:11][C:10]1[N+:6]2[CH2:5][CH2:4][CH2:3][CH2:2][C:1]=2[S:7][C:9]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 97919Bromo(phenyl)acetic acidHCID 30306372-Piperidinethione

Product 1

HCID 12922546HCID 12922546, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

An acetone solution of 3.51 g. (0.03 mole) δ-thiovalerolactam and 6.75 g. (0.03 mole) α-bromophenylacetic acid was heated until the solid started to form. After the solution was cooled, the solid was collected which weighed 6.5 g. Recrystallization could be done with acetonitrile. The purified material had a melting point of 188°-192° (dec.).

Workup

  1. customto form
  2. temperatureAfter the solution was cooled
  3. customthe solid was collected which
  4. customRecrystallization

Sources & evidence

ORD record
ord-6f87397d50824a4fb21c34005438cad7
Source dataset
uspto-grants-1981_09
Patent number
US04289697

Reaction notes

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