Phosphorus oxychloride → HCID 86738007, compound

HRID 1577799Notes

Reaction equation

HRID 1577799 reaction equation
P(Cl)(Cl)(Cl)=O.[C:6]([CH:9]1[CH:11]([C:12]([NH2:14])=O)[C:10]1([CH3:16])[CH3:15])(=[O:8])[CH3:7]>C1C=CC=CC=1>[C:6]([C@H:9]1[C@H:11]([C:12]#[N:14])[C:10]1([CH3:16])[CH3:15])(=[O:8])[CH3:7]

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 20569520HCID 20569520, compound

Product 1

HCID 86738007HCID 86738007, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Phosphorus oxychloride (202.4 g, 1.32 m) was added dropwise to a solution of 3-acetyl-2,2-dimethyl-cyclopropane-1-carboxamide. (34.6 g, 0.22 m) in benzene (140 ml) and the resultant mixture refluxed for 3 hours. Excess reagents were removed in vacuo and the residue dissolved in ether (100 ml). The ether was washed with water (3×60 ml), dried over anhydrous magnesium sulphate and evaporated in vacuo to give a dark oil b.p. 72°-5° C./1.0 mm.

Workup

  1. customExcess reagents were removed in vacuo
  2. dissolutionthe residue dissolved in ether (100 ml)
  3. washThe ether was washed with water (3×60 ml)
  4. dry with materialdried over anhydrous magnesium sulphate
  5. customevaporated in vacuo

Sources & evidence

ORD record
ord-bdae3515f7934a72aacc7030a848dbf0
Source dataset
uspto-grants-1981_09
Patent number
US04289711

Reaction notes

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