Thiomorpholine → HCID 20569583, compound

HRID 1577800Notes

Reaction equation

HRID 1577800 reaction equation
[Br:1][C:2]1[C:3](Cl)=[C:4]([N+:10]([O-:12])=[O:11])[C:5]([CH3:9])=[N:6][C:7]=1[CH3:8].[NH:14]1[CH2:19][CH2:18][S:17][CH2:16][CH2:15]1>C(O)(C)C>[Br:1][C:2]1[C:3]([N:14]2[CH2:19][CH2:18][S:17][CH2:16][CH2:15]2)=[C:4]([N+:10]([O-:12])=[O:11])[C:5]([CH3:9])=[N:6][C:7]=1[CH3:8]

Participants

4

Reactant 2

HCID 67164ThiomorpholineHCID 20569585HCID 20569585, compound

Product 1

HCID 20569583HCID 20569583, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

11.68 Grams (0.044 mol) of 5-bromo-4-chloro-2,6-dimethyl-3-nitro-pyridine and 9.11 g (0.088 mol) of thiomorpholine are heated at boiling point for 18 hours in 50 ml of isopropanol. Upon completion of the reaction the solvent is removed, the residue is digested with water, and the yellow precipitate is filtered off with suction and recrystallized from isopropanol.

Workup

  1. customfor 18 hours
  2. customUpon completion of the reaction the solvent
  3. customis removed
  4. filtrationthe yellow precipitate is filtered off with suction
  5. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-a48e4f6c413a4157a3cb3a435da31740
Source dataset
uspto-grants-1981_09
Patent number
US04289765

Reaction notes

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