Benzylamine → 75484-74-1

HRID 1577801Notes

Reaction equation

HRID 1577801 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH3:9])[C:3]=1[N+:10]([O-:12])=[O:11].[CH2:13]([NH2:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(O)(C)C>[ClH:1].[CH2:13]([NH:20][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH3:9])[C:3]=1[N+:10]([O-:12])=[O:11])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 107027254-Chloro-2,6-dimethyl-3-nitropyridine

Product 1

HCID 2056958975484-74-1

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

9.3 Grams (0.05 mol) of 4-chloro-2,6-dimethyl-3-nitropyridine and 10.7 g (0.1 mol) of benzylamine are heated for 5 hours at boiling point in 20 ml of isopropanol. After cooling, the mixture is concentrated, dissolved in water and extracted with chloroform. The chloroform phase is dried with sodium sulfate and concentrated. The residue is converted with ethanolic hydrochloric acid into the hydrochloride and recrystallized from isopropanol.

Workup

  1. temperatureAfter cooling
  2. concentrationthe mixture is concentrated
  3. dissolutiondissolved in water
  4. extractionextracted with chloroform
  5. dry with materialThe chloroform phase is dried with sodium sulfate
  6. concentrationconcentrated
  7. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-29a122e524ff4855ad8c54d9ee8de13d
Source dataset
uspto-grants-1981_09
Patent number
US04289765

Reaction notes

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