Bromine → HCID 20569974, compound

HRID 1577810Notes

Reaction equation

HRID 1577810 reaction equation
BrBr.[CH3:3][CH:4]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)=[N:8][NH:7][C:6](=[O:23])[CH2:5]1>C(O)(=O)C>[CH3:3][C:4]1[C:9]([C:10]2[CH:11]=[CH:12][C:13]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=3)=[CH:14][CH:15]=2)=[N:8][NH:7][C:6](=[O:23])[CH:5]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 20569954HCID 20569954, compound

Product 1

HCID 20569974HCID 20569974, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

18 g of bromine is added dropwise, with stirring, to a solution of 28.2 g of 5-methyl-6-(4'-fluoro-4-biphenyl-yl)-2,3,4,5-tetrahydropyridazin-3-one in 500 ml of acetic acid at 100°; the mixture is then heated for an additional 15 minutes at 100°, cooled and filtered. 5-Methyl-6-(4'-fluoro-4-biphenylyl)-2,3-dihydropyridazin-3-one is obtained. m.p. 245°-247°.

Workup

  1. temperaturethe mixture is then heated for an additional 15 minutes at 100°
  2. temperaturecooled
  3. filtrationfiltered

Sources & evidence

ORD record
ord-9a8e6d7ac2fd4392bf2c74149eb2e53e
Source dataset
uspto-grants-1981_09
Patent number
US04289774

Reaction notes

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