HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → 2-Chloro-10-[3-(imidazol-1-yl)-propionyl]-phenothiazine-5-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 2-Chlorophenothiazine | HCID 7088 | — |
| Reactant | 3-Chloropropionyl chloride | HCID 69364 | — |
| Reactant | 3-Chloro-1-(2-chloro-phenothiazin-10-yl)-propan-1-one | HCID 1713184 | — |
| Reactant | 2-Chloro-10-(3-chloropropionyl)-phenothiazine-5-oxide | HCID 20569684 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 2-Chloro-10-[3-(imidazol-1-yl)-propionyl]-phenothiazine-5-oxide | HCID 20569797 | — |
Reaction Steps
A mixture of 68 g (0.2 mole) of 2-chloro-10-(3-chloropropionyl)-phenothiazine-5-oxide [obtainable by boiling 2-chlorophenothiazine with 3-chloropropionyl chloride in benzene for 12 hours and oxidizing the resulting 2-chloro-10-(3-chloropropionyl)-phenothiazine (melting point 110°-112°) with H2O2 ] and 68 g (1 mole) of imidazole is stirred at 110°-115° for 30 minutes. Working up in the customary manner gives 2-chloro-10-[3-(imidazol-1-yl)-propionyl]-phenothiazine-5-oxide, melting point 148°-149°. Hydrochloride, melting point 222°-223°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04289768 |
| Source dataset | uspto-grants-1981_09 |
| ORD ID | ord-9ca568d6ef2d4db99a7ab115be2ce2d8 |
| Source note | uspto-grants-1981_09 |