反应详情

A mixture of 68 g (0.2 mole) of 2-chloro-10-(3-chloropropionyl)-phenothiazine-5-oxide [obtainable by boiling 2-chlorophenothiazine with 3-chloropropionyl chloride in benzene for 12 hours and oxidizing the resulting 2-chloro-10-(3-chloropropionyl)-phenothiazine (melting point 110°-112°) with H2O2 ] and 68 g (1 mole) of imidazole is stirred at 110°-115° for 30 minutes. Working up in the customary manner gives 2-chloro-10-[3-(imidazol-1-yl)-propionyl]-phenothiazine-5-oxide, melting point 148°-149°. Hydrochloride, melting point 222°-223°.

1. customfor 12 hours