HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenothiazine → 10-[3-(Imidazol-1-yl)-propionyl]-phenothiazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenothiazine | HCID 7108 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 3-(1H-imidazol-1-yl)propanoic acid | HCID 2794718 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 10-[3-(Imidazol-1-yl)-propionyl]-phenothiazine | HCID 20569771 | — |
Reaction Steps
A mixture of 19.9 g of phenothiazine, 14 g of 3-(imidazol-1-yl)-propionic acid, 20.6 g of dicyclohexylcarbodiimide, and 200 ml of ethyl acetate is stirred for 30 minutes at 0°, and then for 3 hours at 20°. It is worked up in the customary manner to give 10-[3-(imidazol-1-yl)-propionyl]-phenothiazine, melting point 150°-152°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04289768 |
| Source dataset | uspto-grants-1981_09 |
| ORD ID | ord-4be27e812e3a40ad9354db59caa194d5 |
| Source note | uspto-grants-1981_09 |