HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → 2-Chloro-10-[3-(imidazol-1-yl)-propionyl]-phenothiazine-5-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 3-(1H-imidazol-1-yl)propanoic acid | HCID 2794718 | — |
| Reactant | 2-chloro-10H-phenothiazine 5-oxide | HCID 6451335 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Chloro-10-[3-(imidazol-1-yl)-propionyl]-phenothiazine-5-oxide | HCID 20569797 | — |
Reaction Steps
A mixture of 25 g of 2-chloro-phenothiazine-5-oxide, 14 g of 3-(imidazol-1-yl)-propionic acid, 20.6 g of dicyclohexylcarbodiimide and 250 ml of tetrahydrofuran is stirred for 1 hour at 0° and then for 2 hours at 30°. It is worked up in the customary manner to give 2-chloro-10-[3-(imidazol-1-yl)-propionyl]-phenothiazine-5-oxide, melting point 148°-149°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04289768 |
| Source dataset | uspto-grants-1981_09 |
| ORD ID | ord-7e3132de106e4942a3015d0e8f2a871e |
| Source note | uspto-grants-1981_09 |