反应详情

A mixture of 25 g of 2-chloro-phenothiazine-5-oxide, 14 g of 3-(imidazol-1-yl)-propionic acid, 20.6 g of dicyclohexylcarbodiimide and 250 ml of tetrahydrofuran is stirred for 1 hour at 0° and then for 2 hours at 30°. It is worked up in the customary manner to give 2-chloro-10-[3-(imidazol-1-yl)-propionyl]-phenothiazine-5-oxide, melting point 148°-149°.

1. waitfor 2 hours at 30°