Hydrogen Peroxide → 2-Chloro-10-[3-(imidazol-1-yl)-propionyl]-phenothiazine-5,5-dioxide

HRID 1577828Notes

Reaction equation

HRID 1577828 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12](=[O:16])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]([C:17](=[O:25])[CH2:18][CH2:19][N:20]3[CH:24]=[CH:23][N:22]=[CH:21]3)[C:4]=2[CH:3]=1.[OH:26]O>C(O)(=O)C>[Cl:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12](=[O:26])(=[O:16])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]([C:17](=[O:25])[CH2:18][CH2:19][N:20]3[CH:24]=[CH:23][N:22]=[CH:21]3)[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 205697972-Chloro-10-[3-(imidazol-1-yl)-propionyl]-phenothiazine-5-oxide

Product 1

HCID 205697502-Chloro-10-[3-(imidazol-1-yl)-propionyl]-phenothiazine-5,5-dioxide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 1 g of 2-chloro-10-[3-(imidazol-1-yl)-propionyl]-phenothiazine-5-oxide, 4 ml of 30% H2O2 and 40 ml of acetic acid is stirred for 3 hours at 45° and is worked up in the customary manner to give 2-chloro-10-[3-(imidazol-1-yl)-propionyl]-phenothiazine-5,5-dioxide, melting point 134°-135° (decomposition). Hydrochloride, melting point 200°-201°.

Sources & evidence

ORD record
ord-b8ed1ee074c14aa0bc439ff1fff7534f
Source dataset
uspto-grants-1981_09
Patent number
US04289768

Reaction notes

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