HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 669036, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 1-Benzyl-4-piperidylamine | HCID 415852 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 669036 | HCID 669036 | 35.5% |
Reaction Steps
Methanesulphonyl chloride (2.5 g) was added dropwise to a stirred solution of 1-benzyl-4-aminopiperidine (4 g) and triethylamine (4 ml) in chloroform (40 ml) at room temperature. After 20 minutes, water (40 ml) was added, the organic layer separated, dried (MgSO4), and evaporated in vacuo to give an oil which crystallized from ether to give N-(1-benzylpiperid-4-yl)methanesulphonamide (2 g, m.p. 135°-6°).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04289772 |
| Source dataset | uspto-grants-1981_09 |
| ORD ID | ord-1cc4f95a2926480790f451fd35d3e064 |
| Source note | uspto-grants-1981_09 |