Water → HCID 669036, compound

HRID 1577840Notes

Reaction equation

HRID 1577840 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[CH2:6]([N:13]1[CH2:18][CH2:17][CH:16]([NH2:19])[CH2:15][CH2:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(N(CC)CC)C.O>C(Cl)(Cl)Cl>[CH2:6]([N:13]1[CH2:18][CH2:17][CH:16]([NH:19][S:2]([CH3:1])(=[O:4])=[O:3])[CH2:15][CH2:14]1)[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 4158521-Benzyl-4-piperidylamine

Product 1

HCID 669036HCID 669036, compoundYield 35.5%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Methanesulphonyl chloride (2.5 g) was added dropwise to a stirred solution of 1-benzyl-4-aminopiperidine (4 g) and triethylamine (4 ml) in chloroform (40 ml) at room temperature. After 20 minutes, water (40 ml) was added, the organic layer separated, dried (MgSO4), and evaporated in vacuo to give an oil which crystallized from ether to give N-(1-benzylpiperid-4-yl)methanesulphonamide (2 g, m.p. 135°-6°).

Workup

  1. customthe organic layer separated
  2. dry with materialdried (MgSO4)
  3. customevaporated in vacuo
  4. customto give an oil which
  5. customcrystallized from ether

Sources & evidence

ORD record
ord-1cc4f95a2926480790f451fd35d3e064
Source dataset
uspto-grants-1981_09
Patent number
US04289772

Reaction notes

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