反应详情

Ethyl 3-(piperid-4-yl)propionate (7 g) (prepared similarly to Preparation 21 A using ethyl alcohol in place of methyl alcohol) was dissolved in ethanolic methylamine (33%, 50 ml) and heated in a stainless steel bomb for 6 hours at 120°. The mixture was then evaporated to dryness in vacuo and the residue partitioned between 2 N NaOH (20 ml) and chloroform (40 ml). The chloroform layer was dried (Na2CO3) and evaporated to give N-methyl-3-(piperid-4-yl)propionamide (6 g) as a crude oil.

1. customThe mixture was then evaporated to dryness in vacuo
2. customthe residue partitioned between 2 N NaOH (20 ml) and chloroform (40 ml)
3. dry with materialThe chloroform layer was dried (Na2CO3)
4. customevaporated