HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-(Pyrid-4-yl)butyroyl chloride hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Pyridin-4-YL-butyric acid hydrochloride | HCID 46735945 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | 4-(Pyrid-4-yl)butyroyl chloride hydrochloride | HCID 20569940 | — |
Reaction Steps
4-(Pyrid-4-yl)butyric acid hydrochloride (ca. 35 g) in dichloroethane (250 ml) and dimethylformamide (0.5 ml) was treated with thionyl chloride (100 ml). The vigorous exothermic reaction was allowed to subside and then the mixture was heated under reflux for 10 minutes, followed by evaporation to dryness in vacuo to give crude 4-(pyrid-4-yl)butyroyl chloride hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04289772 |
| Source dataset | uspto-grants-1981_09 |
| ORD ID | ord-a207383eb217417cae2155479e9acfab |
| Source note | uspto-grants-1981_09 |