反应详情

4-(Pyrid-4-yl)butyric acid hydrochloride (ca. 35 g) in dichloroethane (250 ml) and dimethylformamide (0.5 ml) was treated with thionyl chloride (100 ml). The vigorous exothermic reaction was allowed to subside and then the mixture was heated under reflux for 10 minutes, followed by evaporation to dryness in vacuo to give crude 4-(pyrid-4-yl)butyroyl chloride hydrochloride.

1. customThe vigorous exothermic reaction
2. temperaturethe mixture was heated
3. temperatureunder reflux for 10 minutes
4. customfollowed by evaporation to dryness in vacuo