4-Pyridinebutanamide → 4-(Piperidin-4-yl)butanamide

HRID 1577848Notes

Reaction equation

HRID 1577848 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][CH2:9][C:10]([NH2:12])=[O:11])=[CH:3][CH:2]=1.[H][H]>C(O)(=O)C.[Pt]=O>[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][CH2:9][C:10]([NH2:12])=[O:11])[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 121366404-PyridinebutanamideHCID 178418361HCID 178418361, compound

Product 1

HCID 219492354-(Piperidin-4-yl)butanamide

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 176Acetic AcidSolvent

Procedure

The crude amide was dissolved in glacial acetic acid and hydrogenated at 60°/60 p.s.i. over a platinum oxide catalyst until uptake of hydrogen ceased. The catalyst was removed by filtration and the filtrate was evaporated in vacuo to give crude 4-(piperid-4-yl)butyramide as an oil.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-84b1bf2f9a3a48a78a60fdfdc7b7000f
Source dataset
uspto-grants-1981_09
Patent number
US04289772

Reaction notes

Loading…