Picolyl chloride hydrochloride → N-Cyano-N'-(2-propyn-1-yl)-N"-{2-[(2-pyridyl)methylthio]ethyl}guanidine

HRID 1577918Notes

Reaction equation

HRID 1577918 reaction equation
[C:1]([NH:3][C:4]([NH:9][CH2:10][C:11]#[CH:12])=[N:5][CH2:6][CH2:7][SH:8])#[N:2].Cl.Cl[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=1>>[C:1]([NH:3][C:4]([NH:9][CH2:10][C:11]#[CH:12])=[N:5][CH2:6][CH2:7][S:8][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=1)#[N:2]

Participants

3

Reactant 2

HCID 23392Picolyl chloride hydrochlorideHCID 136182246N-Cyano-N'-propargyl-N"-(2-mercaptoethyl)guanidine

Product 1

HCID 136023173N-Cyano-N'-(2-propyn-1-yl)-N"-{2-[(2-pyridyl)methylthio]ethyl}guanidine

Procedure

The ethanolic solution of the product of Step A is reacted with about an equimolar amount of 2-chloromethylpyridine hydrochloride and about two equivalents of base to produce the title product.

Sources & evidence

ORD record
ord-9acfcd3a79d04c1a9faba53d6cdc1905
Source dataset
uspto-grants-1981_09
Patent number
US04289876

Reaction notes

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