Ethanol → HCID 53656875, compound

HRID 1577926Notes

Reaction equation

HRID 1577926 reaction equation
Cl.[NH2:2][NH:3][C:4]([NH2:6])=[O:5].[C:7](=[O:10])([O-])O.[K+].C(O)C.[CH2:15]([O:17][C:18](=O)[C:19]#C)[CH3:16]>O>[CH2:15]([O:17][C:18](=[N:2][NH:3][C:4]([NH2:6])=[O:5])[CH2:19][CH:7]=[O:10])[CH3:16]

Participants

6

Reactant 4

HCID 702EthanolHCID 11236Semicarbazide hydrochlorideHCID 12182Ethyl propiolateHCID 516893Potassium Bicarbonate

Product 1

HCID 53656875HCID 53656875, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

11.15 g (0.1 mole) semicarbazide hydrochloride are dissolved in 10 ml water in a three neck 100 ml round flask with stirrer and thermometer and 10.0 g (0.1 mole) potassium hydrogen carbonate are added and then 10 ml ethanol are employed to thin. To this during 5 minutes are added drop by drop 9.8 g (0.1 mole) propiolic acid ethyl ester. The reaction temperature is kept for 4 hours at about 30° C. and a thick crystal paste forms slowly. After standing over night the product is cooled down in an ice bath and thinned with 10 ml water. The crystals are sucked off, are washed with 10 ml water and dried in vacuo at 40° C. to constant weight.

Workup

  1. waitAfter standing over night
  2. washare washed with 10 ml water
  3. customdried in vacuo at 40° C. to constant weight

Sources & evidence

ORD record
ord-066af236c2284bb19aaa098f492f3ecc
Source dataset
uspto-grants-1981_09
Patent number
US04289897

Reaction notes

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