HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → Hydroxyprogesterone Impurity 35
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) | HCID 24670 | — |
| Reactant | 17,21-Bis(acetyloxy)pregn-4-ene-3,20-dione | HCID 102165 | — |
| Product | Hydroxyprogesterone Impurity 35 | HCID 15674000 | 83% |
Reaction Steps
One gram of 17α,21-diacetoxy-4-pregnene-3,20-dione is heated analogously to Example 1 in "Dowtherm" for 80 minutes to 285° C., worked up, separated, and combined. Recrystallization from hexane/ethyl acetate yields 700 mg of 21-acetoxy-4,16-pregnadiene-3,20-dione (83% of theory), m.p. 146°-148° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04290963 |
| Source dataset | uspto-grants-1981_09 |
| ORD ID | ord-4242d5c10ba5444d8555edf21e1c592d |
| Source note | uspto-grants-1981_09 |