Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1578025Generated: October 26, 2026

1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → (11beta)-21-(Acetyloxy)-11-hydroxypregna-1,4,16-triene-3,20-dione

https://huagongshe.com/reaction/1578025

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)HCID 24670—
ReactantPrednisolone 17,21-diacetateHCID 14233395—
Product(11beta)-21-(Acetyloxy)-11-hydroxypregna-1,4,16-triene-3,20-dioneHCID 10236581%

Reaction Steps

One gram of 17α,21-diacetoxy-11β-hydroxy-1,4- pregnadiene-3,20-dione is treated analogously to Example 1 in "Dowtherm" for 50 minutes at 250° C. and worked up. Recrystallization from isopropyl ether yields 700 mg of 21-acetoxy-11β-hydroxy-1,4,16-pregnatriene-3,20-dione (81% of theory).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04290963
Source datasetuspto-grants-1981_09
ORD IDord-3f6fb4f1f2ab440592833401d2ffe519
Source noteuspto-grants-1981_09