反应详情

With stirring, 975 g (4.37 moles) of 3,3-dimethyl-12-ethyl-1-azacyclododecene (prepared in accordance with Example β) are added dropwise in the course of about 35 minutes to a solution of 450 g (4.6 moles) of sulfuric acid in 600 g of water. The clear, slightly yellowish solution is then treated with steam for 20 minutes in order to remove any aldehyde impurities. The aqueous solution is subsequently stirred in an autoclave for 3 hours at 50° C. under an oxygen pressure of 20 bar. The acid reaction mixture is neutralised with sodium hydroxide solution, affording 820 g (3.2 moles) of 2,2-dimethyl-11-ethyl-11-aminoundecanoic acid, corresponding to a yield of 73% of theory. Melting point: 164°-165° C.

1. additionThe clear, slightly yellowish solution is then treated with steam for 20 minutes in order
2. customto remove any aldehyde impurities
3. stirringThe aqueous solution is subsequently stirred in an autoclave for 3 hours at 50° C. under an oxygen pressure of 20 bar
4. customThe acid reaction mixture