Sulfuric Acid → HCID 20518072, compound

Participants

Reaction Steps

With stirring, 975 g (4.37 moles) of 3,3-dimethyl-12-ethyl-1-azacyclododecene (prepared in accordance with Example β) are added dropwise in the course of about 35 minutes to a solution of 450 g (4.6 moles) of sulfuric acid in 600 g of water. The clear, slightly yellowish solution is then treated with steam for 20 minutes in order to remove any aldehyde impurities. The aqueous solution is subsequently stirred in an autoclave for 3 hours at 50° C. under an oxygen pressure of 20 bar. The acid reaction mixture is neutralised with sodium hydroxide solution, affording 820 g (3.2 moles) of 2,2-dimethyl-11-ethyl-11-aminoundecanoic acid, corresponding to a yield of 73% of theory. Melting point: 164°-165° C.

Provenance & Evidence