Hydrochloric Acid → HCID 70455578, compound

HRID 1578090Notes

Reaction equation

HRID 1578090 reaction equation
[CH:1]1(C(O)=O)[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]([C:14]([OH:16])=[O:15])[CH2:3][NH:2]1.[ClH:20]>O>[ClH:20].[CH2:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]([C:14]([OH:16])=[O:15])[CH2:3][NH:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12773699HCID 12773699, compound

Product 1

HCID 70455578HCID 70455578, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

Four (4) g; 0.16 mole of 1,2,3,4-tetrahydro-β-carboline-1,4-dicarboxylic acid (TR-8021) prepared in Example 1 was mixed with 40 ml concentrated HCl and 120 ml of water. The mixture was refluxed at 80° C. (oil-bath) for 2 hours. A white precipitate was collected by filtration, and washed with small amount of cooled water. The crude material was boiled in water, filtered through celite and cooled. The precipitate was collected and dried in the oven at 60° C. Yield: 3 g; (74%). MP 280°-281° C.

Workup

  1. filtrationA white precipitate was collected by filtration
  2. washwashed with small amount of cooled water
  3. filtrationfiltered through celite
  4. temperaturecooled
  5. customThe precipitate was collected
  6. customdried in the oven at 60° C

Sources & evidence

ORD record
ord-d859d9346f724befac40ea7c1760622b
Source dataset
uspto-grants-1981_09
Patent number
US04291039

Reaction notes

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