Hydrochloric Acid → 4H-Pyrido(1,2-a)pyrimidin-4-one, 7-chloro-3-ethyl-2-methyl-, monohydrochloride

HRID 1578095Notes

Reaction equation

HRID 1578095 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][N:5]2[C:6](=[O:10])[C:7]=1[CH2:8][CH3:9].Cl>C(O)C>[ClH:15].[CH3:1][C:2]1[N:3]=[C:4]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][N:5]2[C:6](=[O:10])[C:7]=1[CH2:8][CH3:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 3053807HCID 3053807, compound

Product 1

HCID 30538064H-Pyrido(1,2-a)pyrimidin-4-one, 7-chloro-3-ethyl-2-methyl-, monohydrochlorideYield 97%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

4.45 g. of 2-methyl-3-ethyl-7-chloro-4-oxo-4H-pyrido[1,2-a]-pyrimidine are dissolved in ethanol, with heating, then 25 ml. of a 28% by weight solution of hydrogen chloride in ethanol is added to the solution obtained. The precipitated crystals are filtered off and washed with ethanol. 5.01 g. (97%) of 2-methyl-3-ethyl-7-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine hydrochloride are obtained, M.P. 176° to 180° C.

Workup

  1. temperaturewith heating
  2. customobtained
  3. filtrationThe precipitated crystals are filtered off
  4. washwashed with ethanol

Sources & evidence

ORD record
ord-8bb81b3020ef453e9fa147ec43ea78da
Source dataset
uspto-grants-1981_09
Patent number
US04291036

Reaction notes

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