Salicylic Acid → HCID 178436829, compound

HRID 1578099Notes

Reaction equation

HRID 1578099 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[N:7]2[C:10]([CH3:14])=[CH:11][CH:12]=[CH:13][C:6]2=[N:5][C:4]=1[CH3:15])[CH3:2].[C:16]([OH:25])(=[O:24])[C:17]1[C:18](=[CH:20][CH:21]=[CH:22][CH:23]=1)[OH:19]>CC(C)=O>[C:16]([O-:25])(=[O:24])[C:17]1[C:18](=[CH:20][CH:21]=[CH:22][CH:23]=1)[OH:19].[CH2:1]([C:3]1[C:8](=[O:9])[N:7]2[C:10]([CH3:14])=[CH:11][CH:12]=[CH:13][C:6]2=[NH+:5][C:4]=1[CH3:15])[CH3:2]

Participants

4

Reactant 2

HCID 338Salicylic AcidHCID 93406CH 150

Product 1

HCID 178436829HCID 178436829, compoundYield 67.6%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

10 g. of 3-ethyl-2,6-dimethyl-4-oxo-4H-pyrido(1,2-a)pyrimidine are dissolved in 100 ml. of acetone with heating and a solution of 7 g. of salicylic acid in 100 ml. of acetone is added. The reaction mixture is brought to a boil, then cooled. The precipitated crystals are filtered off, washed with acetone and dried. 11.5 g. (67.6%) of 3-ethyl-2,6-dimethyl-4-oxo-4H-pyrido(1,2-a)pyrimidinium salicylate are obtained, melting at 126° to 128° C. after recrystallization from ethanol.

Workup

  1. temperaturecooled
  2. filtrationThe precipitated crystals are filtered off
  3. washwashed with acetone
  4. customdried

Sources & evidence

ORD record
ord-dbfb64a1257c42e6bd99905d745574ef
Source dataset
uspto-grants-1981_09
Patent number
US04291036

Reaction notes

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