反应详情

2.55 (0.01 mol) of 7-chloro-6-fluoro-1-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, 3.5 cm3 of morpholine (0.01 mol) and 34 cm3 of DMSO were heated at 110° C. for 7 hours, whilst stirring. The reaction product precipitated after heating for 5 hours. After cooling, the mixture was diluted with water (100 cm3) and the solid was filtered off, washed with water and recrystallised from DMF (45 cm3). 1 g of 6-fluoro-1-methyl-7-morpholino-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, m.p. 316° C. (decomposition), was obtained.

1. customThe reaction product precipitated
2. temperatureafter heating for 5 hours
3. temperatureAfter cooling
4. additionthe mixture was diluted with water (100 cm3)
5. filtrationthe solid was filtered off
6. washwashed with water
7. customrecrystallised from DMF (45 cm3)