Morpholine → 6-Fluoro-1-methyl-7-(morpholin-4-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Beteiligte Stoffe

Reaktionsschritte

2.55 (0.01 mol) of 7-chloro-6-fluoro-1-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, 3.5 cm3 of morpholine (0.01 mol) and 34 cm3 of DMSO were heated at 110° C. for 7 hours, whilst stirring. The reaction product precipitated after heating for 5 hours. After cooling, the mixture was diluted with water (100 cm3) and the solid was filtered off, washed with water and recrystallised from DMF (45 cm3). 1 g of 6-fluoro-1-methyl-7-morpholino-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, m.p. 316° C. (decomposition), was obtained.

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