1-Methylpiperazine → HCID 12944916, compound

Participants

Reaction Steps

1.65 g (0.005 mol) of 1-benzyl-7-chloro-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, 2.5 cm3 of 1-methylpiperazine and 12 cm3 of pyridine were heated under reflux for 9 hours. The reaction product was isolated as indicated in Example 35 and purified by recrystallisation from methylcellosolve (20 cm3). 1 g of 1-benzyl-6-fluoro-7-(4-methylpiperazinyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, m.p. 266° C., was obtained.

Provenance & Evidence