1-Methylpiperazine → HCID 12944916, compound

HRID 1578276Notes

Reaction equation

HRID 1578276 reaction equation
[CH2:1]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([F:19])=[C:15](Cl)[CH:16]=2)[C:11](=[O:20])[C:10]([C:21]([OH:23])=[O:22])=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:24][N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>N1C=CC=CC=1>[CH2:1]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([F:19])=[C:15]([N:28]3[CH2:29][CH2:30][N:25]([CH3:24])[CH2:26][CH2:27]3)[CH:16]=2)[C:11](=[O:20])[C:10]([C:21]([OH:23])=[O:22])=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 12733884HCID 12733884, compound

Product 1

HCID 12944916HCID 12944916, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1.65 g (0.005 mol) of 1-benzyl-7-chloro-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, 2.5 cm3 of 1-methylpiperazine and 12 cm3 of pyridine were heated under reflux for 9 hours. The reaction product was isolated as indicated in Example 35 and purified by recrystallisation from methylcellosolve (20 cm3). 1 g of 1-benzyl-6-fluoro-7-(4-methylpiperazinyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid, m.p. 266° C., was obtained.

Workup

  1. temperatureunder reflux for 9 hours
  2. customThe reaction product was isolated
  3. custompurified by recrystallisation from methylcellosolve (20 cm3)

Sources & evidence

ORD record
ord-d2f602a0ce6f4425a6aad501c1954576
Source dataset
uspto-grants-1981_09
Patent number
US04292317

Reaction notes

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