Diethyl Ether → HCID 68128085, compound

HRID 1578344Notes

Reaction equation

HRID 1578344 reaction equation
[Cl:1]CC(OC(=O)CCl)=O.[NH2:10][C:11]1[CH:20]=[CH:19][CH:18]=[C:17]2[C:12]=1[CH2:13][CH2:14][CH2:15][CH2:16]2.[CH2:21]([O:23]CC)[CH3:22]>>[Cl:1][C:16]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:17]=1[CH2:18][CH2:19][CH2:20][CH:11]2[NH:10][C:21]([CH3:22])=[O:23]

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 10946Chloroacetic anhydrideHCID 166715-Tetralinylamine

Product 1

HCID 68128085HCID 68128085, compound

Procedure

An ethereal solution of 90 g of chloroacetic acid anhydride is added dropwise to 73.6 g of 5-amino-1,2,3,4-tetrahydronapthalene in 1000 ml of diethyl ether. The temperature should not exceed 30°. The mixture is stirred for a further half hour at room temperature, then cooled to 0° and the precipitated product filtered off. After recrystallisation from ethanol, there is obtained 100 g of 5-chloroacetamino-1,2,3,4-tetrahydronaphthalene having a melting point of 155° - 157° (compound No. 2).

Workup

  1. customexceed 30°
  2. temperaturecooled to 0°
  3. filtrationthe precipitated product filtered off
  4. customAfter recrystallisation from ethanol

Sources & evidence

ORD record
ord-9f3e43a27881410cb3d525a782763342
Source dataset
uspto-grants-1976_02
Patent number
US03936293

Reaction notes

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