Hydrochloric Acid → HCID 178426633, compound

HRID 1578380Notes

Reaction equation

HRID 1578380 reaction equation
[NH2:1][C:2]([NH2:4])=[S:3].[C:5]([CH2:8][C:9](=O)[CH3:10])(=O)[CH3:6].[ClH:12]>C(O)C>[ClH:12].[SH:3][C:2]1[N:4]=[C:9]([CH3:10])[CH:8]=[C:5]([CH3:6])[N:1]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 31261AcetylacetoneHCID 2723790Thiourea

Product 1

HCID 178426633HCID 178426633, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

76 Grams (1.0 mole) of thiourea was suspended in a solution of 120 g. (1.2 moles) of acetylacetone in 2,500 ml. of ethanol. The resulting suspension was mixed with 250 ml. of concentrated hydrochloric acid, and then reacted under reflux for 2 hours. After completion of the reaction, the reaction liquid was cooled, whereby beautiful yellow needle-like crystals of 2-mercapto-4,6-dimethyl-pyrimidine hydrochloride were formed. The reaction liquid was allowed to stand overnight to sufficiently deposit the crystals, which were then recovered by filtration and dried to obtain 140 g. of 2-mercapto-4,6-dimethyl-pyrimidine hydrochloride in yield of 80 %.

Workup

  1. additionThe resulting suspension was mixed with 250 ml
  2. temperatureunder reflux for 2 hours
  3. customAfter completion of the reaction
  4. customthe reaction liquid
  5. temperaturewas cooled

Sources & evidence

ORD record
ord-aff99b0672bb49dc8065de0aabe1ef6d
Source dataset
uspto-grants-1976_02
Patent number
US03936452

Reaction notes

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