Hydrochloric Acid → 4-[4-(Trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine--hydrogen chloride (1/1)

Participants

Reaction Steps

A solution of 4.9 g. of 4-hydroxy-4-(α,α,α-trifluoro-p-tolyl)piperidine in 33 ml. of 37% hydrochloric acid solution and 66 ml. of acetic acid is stirred at reflux temperature for 18 hours. The solution is evaporated and the residue is triturated with acetone to give white crystals, m.p. 213°-215°C.

Provenance & Evidence