反应详情

A solution of 4.9 g. of 4-hydroxy-4-(α,α,α-trifluoro-p-tolyl)piperidine in 33 ml. of 37% hydrochloric acid solution and 66 ml. of acetic acid is stirred at reflux temperature for 18 hours. The solution is evaporated and the residue is triturated with acetone to give white crystals, m.p. 213°-215°C.

1. temperatureat reflux temperature for 18 hours
2. customThe solution is evaporated
3. customthe residue is triturated with acetone
4. customto give white crystals, m.p. 213°-215°C.