4-Phenylpiperidine → 1-Acetyl-3-[2-(4-phenylpiperidino)ethyl]indoline

HRID 1578406Notes

Reaction equation

HRID 1578406 reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]([CH2:13][CH2:14]Br)[CH2:5]1)(=[O:3])[CH3:2].[C:16]1([CH:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]([CH2:13][CH2:14][N:25]2[CH2:26][CH2:27][CH:22]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:23][CH2:24]2)[CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 698734-PhenylpiperidineHCID 215599751-[3-(2-bromoethyl)-2,3-dihydro-1H-indol-1-yl]ethanone

Product 1

HCID 215599591-Acetyl-3-[2-(4-phenylpiperidino)ethyl]indoline

Procedure

In the manner described in Example 1, reaction of 1-acetyl-3-(2-bromoethyl)indoline with 4-phenylpiperidine gives a solid that is recrystallized from dilute ethanol to give white crystals, m.p. 92°-93°C.

Workup

  1. customgives a solid
  2. customthat is recrystallized from dilute ethanol
  3. customto give white crystals, m.p. 92°-93°C.

Sources & evidence

ORD record
ord-3cd22a2ea4474d828f79849c21380999
Source dataset
uspto-grants-1976_02
Patent number
US03936464

Reaction notes

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