Hydrochloric Acid → HCID 21823695, compound

HRID 1578491Notes

Reaction equation

HRID 1578491 reaction equation
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][C:4]=1[C:10](=[O:15])[CH2:11][S:12]([CH3:14])=[O:13].[N:16]([O-])=O.[Na+]>O>[Cl:9][C:6]1[CH:5]=[C:4]2[C:3](=[CH:8][CH:7]=1)[NH:2][N:16]=[C:11]([S:12]([CH3:14])=[O:13])[C:10]2=[O:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 21823692HCID 21823692, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 21823695HCID 21823695, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

500 ml of 3N HCl was chilled to 0° in an ice-salt bath, and 10 g of 2'-amino-5'-chloro-2-(methylsulfinyl)acetophenone was added. The mixture was stirred until a clear solution was obtained, and a solution of 3.45 g of NaNO2 in 20 ml of H2O was added with stirring at ca. 0°-3°. The solution became first orange colored, and then a yellow precipitate formed. The ice bath was removed, and the mixture was stirred until room temperature was attained. The precipitate was filtered off, washed with H2O, and recrystallized from dimethylformamide, mp. 267°-72°; yield 5 g (44%).

Workup

  1. customwas obtained
  2. stirringwith stirring at ca. 0°-3°
  3. customa yellow precipitate formed
  4. customThe ice bath was removed
  5. stirringthe mixture was stirred until room temperature
  6. filtrationThe precipitate was filtered off
  7. washwashed with H2O
  8. customrecrystallized from dimethylformamide, mp. 267°-72°

Sources & evidence

ORD record
ord-4d15bb1eed9e46389ded8c92690e17d8
Source dataset
uspto-grants-1976_02
Patent number
US03937704

Reaction notes

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