Acetohydrazide → HCID 12207321, compound

HRID 1578525Notes

Reaction equation

HRID 1578525 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[N:9]=[C:10]=[S:11].[C:12]([NH:15][NH2:16])(=[O:14])[CH3:13]>C1COCC1>[C:12]([NH:15][NH:16][C:10]([NH:9][C:3]1[CH:4]=[C:5]([CH3:8])[CH:6]=[CH:7][C:2]=1[Cl:1])=[S:11])(=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 14039AcetohydrazideHCID 227520811-Chloro-2-isothiocyanato-4-methylbenzene

Product 1

HCID 12207321HCID 12207321, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

One tenth mole, 18.3 g., of 2-chloro-5-methylphenylisothiocyanate and 11.0 g. (0.15 mole) of acetylhydrazine were refluxed for 7 hours in 500 ml. of THF. After cooling, the insoluble product was collected by filtration. The crude product was collected by filtration. The crude product was washed with water, filtered and dried. The yield was 25 g. of 1-acetyl-4-(2-chloro-5-methylphenyl)-3-thiosemicarbazide, m.p. about 145°-157°C.

Workup

  1. temperatureAfter cooling
  2. filtrationthe insoluble product was collected by filtration
  3. filtrationThe crude product was collected by filtration
  4. washThe crude product was washed with water
  5. filtrationfiltered
  6. customdried

Sources & evidence

ORD record
ord-f7ce56690b79492bbcd3f8d93e8101d4
Source dataset
uspto-grants-1976_02
Patent number
US03937713

Reaction notes

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