反应详情

To a solution of 0.700 g. of N-benzyloxycarbonyl-L-glutamine, 0.665 g. of pentachlorophenol and 0.55 g. of 2,2'-dipyridyl disulfide in 20 ml. of dry acetone is added an acetone solution of 0.655 g. of triphenyl phosphine with stirring at 0°C. The produced precipitates are recovered by filtration and washed successively with a 3 % sodium bicarbonate solution, water and ether and recrystallized from a mixture of dimethylformamide and methanol to give 0.952 g. of the desired product.

1. customThe produced precipitates
2. filtrationare recovered by filtration
3. washwashed successively with a 3 % sodium bicarbonate solution, water and ether
4. customrecrystallized from a mixture of dimethylformamide and methanol
5. customto give 0.952 g