Ethanol → HCID 21559438, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of isobutyraldehyde (0.25 mole), ethanol (0.4 g) and dichloromethane (75 ml) was placed in a three-necked flask fitted with a gas inlet tube, a Dry Ice condenser and a gas outlet tube connected to a gas trap cooled to -78°C. Trifluoromethanesulfenyl chloride (0.22 mole) was added to the cold solution which was maintained under a nitrogen atmosphere. (Caution: It should be noted that trifluoromethanesulfenyl chloride is a highly hazardous material which must be handled with care to avoid inhalation or contact with the skin.) The reaction mixture was then allowed to warm to about 25°C and stirred magnetically until the orange colored solution had become nearly colorless (about 6 hours). The reaction mixture was then distilled. The distillation assembly was connected to a -78°C gas trap to trap any unreacted trifluoromethylsulfenyl chloride. The 2-trifluoromethylthio-2-methylpropionaldehyde, b.p. 108°-116°C was identified by spectral and elemental analyses of a purified sample, b.p. 116°C.

Provenance & Evidence